packing of tablets
alcohol and your health

Many people drink at harmful levels

Consequence of alcohol:

Buy Antabuse Online Australia, Consumption of alcohol in Australia

antabuse
ANTABUSE
1.31 AUDPer pill

The delay of oxidation of ethyl alcohol at a stage of acetic aldehyde causes accumulation it and development of intoxication.

Alcohol is a part of the Australian culture, these are sporting events, marriages, the births, new jobs and a number of intermediate cases are noted with alcoholic beverages.

Australian-drunkards

At the same time Australia not in goes to the list of the countries of high level of alcoholism. Nevertheless, some people drink and increase risk of development of the problems with health connected with alcohol.

The average Australian drinks more than nine liters of pure alcohol a year. It puts Australia in top-30 the countries on alcohol consumption around the world, conceding to France, Great Britain, Ireland and Germany, and these data constantly change.

Statistics in 2014 - 15:

  • 80.6% of Australians at the age of 18 flyings are also more senior took alcohol last year
  • 8.2% took alcohol 12 or more of months back
  • 10.7% never took alcohol
  • Last year alcohol was consumed by more men 85.6%, than women 75.7%
  • 66.2% of all children at the age of 15-17 never took alcohol that it is more in comparison with 2011-12
  • 49.1% of all children at the age of 15-17 never took alcohol
  • Lifelong risk for adults

In the guide of National council to health care and medical researches (NHMRC) of 2009 to risk reduction for health, connected with alcohol intake, it is said that for healthy men and women the use no more than two standard drinks a day is reduced by risk throughout all life. harm from the diseases or injuries connected with alcohol.

Young Australian drunkards

Researches show that a considerable part of young Australians drink so that it is considered harmful. Alcoholism is an everyday occurrence, and it is known that this type of the use is a major factor of injuries, accidents and death. It also promotes violence and crimes. The young people drinking alcohol are often inexperienced and appear in situations of the increased risk. They can make decisions under influence which can have long-term consequences, such as driving be drunk or suicide.

The Examination of households conducted in 2007 within the National strategy of fight against drugs showed that more than 20 percent of children at the age of 14-19 regularly take alcohol. Researches showed that young people who regularly take alcohol have more chances of development of dependence on alcohol, suffer from physical and mental diseases and serious social problems more often. It is known also that alcohol intake by teenagers influences development of a brain.

Alcoholism among young Australians

Researches show that a considerable part of young Australians abuse alcohol. Alcoholism is an everyday occurrence, this type of the use is a major factor of injuries, accidents and death. It also promotes violence and crimes. The young people drinking alcohol are often inexperienced and appear in situations of the increased risk. They can make decisions under influence which can have long-term consequences, such as driving be drunk or suicide.

The Examination of households conducted in 2007 within the National strategy of fight against drugs showed that more than 20 percent of children at the age of 14-19 regularly take alcohol. Researches showed that young people who regularly take alcohol have more chances of development of dependence on alcohol, suffer from physical and mental diseases and serious social problems more often. It is known also that alcohol intake by teenagers influences development of a brain.

Antabuse – a reliable tool from alcoholism, is effective against cancer

Lot drunk and sleeps in a bar

Incidence this global problem which is aggravated with the studied drugs resistance of a tumor. Perspective approach to such unsatisfied need for the improved cancer therapy is conversion of drugs. Here we emphasize the potential of reuse of Disulfiram (Antabuse), old cure for the disgust for alcohol effective against various types of cancer in preclinical trials. Our national epidemiological research showed that patients who constantly applied Disulfiram have lower risk of death from cancer in comparison with those who stopped use of drug at diagnostics. Besides, we identify as a metabolite of Disulfiram responsible for reduction of a tumor, and we provide methods for identification of its primary accumulation in tumors.

Several decades ago accidentally it became clear that Antabuse – the drug which is applied at alcoholism is capable to kill tumor cells. It happened after Antabuse was prescribed the woman with the diagnosis "metastatic cancer" who began to abuse alcohol. As a result the woman lived 10 more years and died in 1971, having dropped out of a drunk window. Opening showed that metastases of a cancer tumor in her body by this moment practically disappeared.

Drug Disulfiram better known under the Antabuse trademark blocks enzyme which catalyzes transformation of toxic acetic aldehyde – a product of metabolism of ethyl alcohol, in acetic acid. As a result acetic aldehyde collects in an organism, making sick, vomiting and tachycardia that does alcohol intake very unpleasant.

In the 1970th scientists confirmed in experiences on experimental animals that Disulfiram kills cancer cells and slows down growth of a tumor. Results of the small clinical trial published in 1993 also demonstrated that drug increases survival at the women operated concerning a breast cancer. Nevertheless this direction of researches actively did not develop, and Antabuse did not attract great interest of oncologists. However recently scientific of Denmark and the Czech Republic not only once again confirmed anticarcinogenic effects of drug, but also found out the mechanism of its action.

Researchers carried out the statistical analysis, using the register of oncological patients of Denmark for 2000-2013 containing data on about a quarter of millions of cases of cancer and also information on medicine which were taken by patients. In the register about 3 thousand patients which appointed Antabuse were found, – about 40% from them accepted it regularly. It turned out that at these patients cancer mortality was one third lower in comparison with those who stopped administration of drug.

In experiments on laboratory mice researchers confirmed that Disulfiram slows down growth of a cancer tumor of a mammary gland and that this effect as it was already known earlier, amplifies additional intake of copper. It turned out that anticarcinogenic activity Disulfiram metabolite – Ditiokarb, the forming complex with copper has. This complex blocks mechanisms which cells use for utilization of defective or not necessary proteinaceous molecules. Accumulation in cells of proteinaceous "garbage" finally leads of them to death.

It is interesting that at the same time Disulfiram does not affect normal, healthy cells even if the patient takes the drug for many years. For yet not found out reasons the complex of a Ditiokarb with copper collects in tumor cells by about 10 times more intensively, than in normal fabrics.

Thus, Disulfiram can prolong life of patients with metastatic cancer, as was shown in small clinical trial on the patients with lung cancer accepting chemotherapy. Now scientists plan carrying out clinical tests on patients with a metastatic breast cancer, a large intestine and a brain. The great advantage of Antabuse is that it is applied in medicine long ago and does not need check on safety. Therefore if clinical tests will confirm its efficiency concerning metastases, doctors will already be able shortly to appoint this drug the cancer patient.

Other articles

What is Antabuse?

Release forms

Tablets of 200 mg: round flat tablets of white or almost white color, with slanted edges, with risky and marking of "CD" — on the one hand risks and "With" — on the other hand risks.

Tablets of 400 mg: round flat tablets of white or almost white color, with slanted edges, with crosswise risky, dividing a tablet into four parts, and marking of "CJ" on the one hand.

Indications to use

Treatment and prevention of a recurrence of an alcoholism.

How should I take Antabuse?

Inside. The sparkling tablet is dissolved in water in the quantity sufficient for full dissolution of drug (half-glass). Treatment is appointed after careful inspection of the patient and a warning of consequences and complications. Accept 200–500 mg 1–2 times a day according to the individual scheme. In 7–10 days carry out Disulfiram - alcoholic test (20–30 ml of vodka after reception of 500 mg of drug), at weak reaction a dose of alcohol increase by 10–20 ml (the maximum dose of vodka of 100-120 ml). Test is repeated in 1–2 days in a hospital and in 3–5 days on an outpatient basis with correction of doses of alcohol and/or drug as necessary. Further it is possible to use a maintenance dose of 150-200 mg/days during 1-3 flyings.

Before buy this medicine, contraindications

Absolute:

Serious illness of a cardiovascular system, acoustic organs (neuritis of an acoustical nerve) and eye (glaucoma, optic neuritis).
  • Bronchial asthma, emphysema of lungs;
  • Pulmonary tuberculosis;
  • Heavy liver failure;
  • Diseases of the haematogenic bodies;
  • Diabetes mellitus;
  • Thyrotoxicosis;
  • Epilepsy and convulsive syndrome of any genesis;
  • Mental diseases;
  • Aggravation of a peptic ulcer;
  • Diseases of kidneys;
  • Malignant tumors;
  • Polyneuritis of any etiology;
  • Pregnancy;
  • Breastfeeding period;
  • The increased individual sensitivity to drug;
  • Cardiovascular diseases in compensation stage;
  • Advanced age (60 years are more senior);
  • A peptic ulcer of a stomach and duodenum in a remission stage;
  • The residual phenomena after disturbance of cerebral circulation;
  • Earlier postponed Disulfiram (Antabuse) psychoses.
  • Side effects

Caused by properties of Disulfiram:

  • Metal taste in a mouth;
  • An unpleasant smell at patients (connected with carbon sulfide);
  • Exceptional cases of hepatitis (similar sometimes meeting at the patients with nickel eczema who do not have alcoholism);
  • Polyneuritis of the lower extremities, optic neuritis;
  • Memory loss, confusion of consciousness;
  • Headaches;
  • Skin allergic manifestations.

Connected with a combination Disulfiram - ethyl alcohol: cases of respiratory insufficiency, cardiovascular collapse, disturbance of a heart rhythm are described; stenocardia, sometimes — a myocardial infarction and also neurologic frustration; wet brain.

Complications at long reception: seldom — the psychoses reminding alcoholic; hepatitis, gastritis; at the persons having cardiovascular diseases thrombosis of vessels of a brain therefore at complaints to paresthesias in extremities and a face it is necessary to cancel drug immediately is possible; aggravation of a polyneuritis.

At reception of doses of alcohol over 50-80 ml of vodka against the background of reception of Disulfiram can develop heavy disturbances of cardiovascular and respiratory systems, hypostases, spasms. In this case carry urgently out therapy, enter analeptics, carry out a symptomatic treatment.

The combination Disulfiram ethanol can cause consciousness oppression, up to a coma, cardiovascular collapse, neurologic complications.

Overdose

Treatment: symptomatic.

Effect of drug is based on blockade of acetaldehyde dehydrogenase which participates in metabolism of ethyl alcohol. It leads to increase in concentration of a metabolite of ethyl alcohol — the acetic aldehyde causing negative feelings (rushes of blood to the person, nausea, vomiting, tachycardia, lowering of the ABP, etc.) which do extremely unpleasant alcohol intake after reception of Antabuse. It leads to conditioned-reflex disgust for taste and a smell of alcoholic drinks.

Pharmacokinetics

After oral administration absorption of Disulfiram is from 70 to 90% of a GIT; it is quickly metabolized, being restored to diethyldithiocarbamate which is removed in a look a glucoses conjugate or turns into diethyl amine and carbon sulfide which part (4–53%) is removed through lungs.

Pharmacological groups

Cure for correction of disturbances for alcoholism and drug addiction

  • Interaction
  • Reaction to ethanol is reduced by ascorbic acid.
  • Contraindication

Alcohol. Reaction of intolerance (rushes of blood, erythema, vomiting, tachycardia). It is necessary to avoid intake of alcoholic drinks and the HP containing alcohol.

Undesirable combinations

  • Isoniazid. Behavior disorder and coordination
  • Nitro-5-imidazoles (metronidazole). Delirious frustration, confusion of consciousness
  • Phenytoinum. Significant and fast rise in level of Phenytoinum in plasma with toxic symptoms (suppression of his metabolism)
  • If the combination cannot be avoided, it is necessary to make clinical observation and control of concentration of drug in plasma in the course and after treatment by Disulfiram

The combinations demanding care

Warfarin (and other oral anticoagulants). The increased effect of oral anticoagulants and danger of bleeding (decrease in disintegration of warfarin in a liver). More frequent control of concentration of warfarin and correction of a dose of anticoagulants within 8 days after cancellation of Antabuse is recommended.

Theophylline. A Disulfiram inhibits theophylline metabolism. As result of it, a dose of theophylline it has to be corrected (a reduced dosage) depending on clinical symptoms and concentration of drug in plasma.

Benzodiazepines. A Disulfiram can exponentiate sedation of benzodiazepines by inhibition of their oxidizing metabolism (especially chlordiazepoxide and diazepam). The dosage of benzodiazepine has to be corrected according to clinical manifestations.

Tricyclic antidepressants. Strengthening of reaction of intolerance of alcohol is possible if patients against the background of reception of Disulfiram take alcoholic drinks.

Information storage and retrieval

At a temperature not above 30 °C.

To store in the place, inaccessible for children.

Period of validity of drug Antabus®5 of years.

Not to apply after the period of validity specified on packing.

Packing and contents

Tablets sparkling 1 table.

Disulfiram of 200 mg / 400 mg.

Excipients: corn starch; povidone; tartaric acid; sodium methoxide; talc; silicon dioxide colloid; magnesium stearate; MKTs.

In container PE of 100 pieces (with a dosage of 200 mg) or 50 pieces (with a dosage of 400 mg); in a pack a cardboard 1 container.

Special instructions

How to buy Antabuse online can be found is here.

Patients should be warned about danger of reaction of intolerance of alcoholic drinks. In case of co-administration with oral anticoagulants it is necessary to exercise more frequent control of maintenance of a prothrombin and correction of doses of anticoagulants that is connected with the increased risk of development of bleeding.

Antabuse should be taken with caution at patients with a renal failure or a hypothyroidism, especially at risk of a possible combination to alcohol.

  • https://search.abs.gov.au/s/search.html?query=alcoholism&collection=abs&form=simple&profile=_default
  • https://www.bbc.com/news/world-australia-39715126
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730499/
  • Https://www.drugs.com/antabuse.html